Recurrent Neuropsychiatric Systemic Lupus Erythematosus Presenting with Primary Central Nervous System Lymphoma

We report the case of a systemic lupus erythematosus (SLE) patient who was diagnosed with cerebritis, vasculitis, Epstein-Barr virus infection, and consequently, lymphoma. The presented to emergency department dysarthria, dysphagia, left-sided hemiparesis, hypesthesia. Initial brain magnetic resonance imaging (MRI) revealed multiple high signal intensities in cortex subcortex. Intravenous methylprednisolone immunoglobulin administration did not improve her symptoms. However, intravenous rituximab improved parenchymal angiographic abnormalities. One month later, she developed another acute Brain MRI rim-enhancing lesions perilesional edema, different from previous lesion. cyclophosphamide symptoms, finally primary central nervous system lymphoma after biopsy. Neurological symptoms chemotherapy. Since incidence is relatively SLE patients, careful diagnosis accurate treatment are needed.